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the candidate will not be responsible for all the modeling, he/she will be expected to develop a critical mindset and a solid understanding of the generated data to actively participate in the interpretation
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of isolated clones using biochemical, biophysical and imaging methods. Engineering of protein tools using chemical or genetic methods for use in a cellular environment. Validation of tools in cellular models
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for their functions in PDE, or co-precipitation with known PDE factors, which could not recover transient and/or unstable interactors. To overcome these limitations, this project aims to a) optimize Cas13-based gene
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encompasses aspects of synthesis, reactivity, and characterization of organometallic compounds under controlled atmosphere, polymerization catalysis, as well as the application of advanced spectroscopic
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the rise of next-generation ultra-sensitive quantum magnetometers, with the only model in France recently installed at Géosciences Montpellier. Thanks to these cutting-edge instruments, this PhD project will
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spanning molecular genetics, genomics, cell biology to biophysics, mathematics and computational modeling. The laboratory is housed at ENS de Lyon, a top-ranking French university, situated in the vibrant
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metabolism in type I interferonopathies within tissues. Using mouse models of these diseases, we will analyze how metabolic alterations contribute to inflammation and tissue damage. We will generate lipidomic
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), Biochemistry (production and purification of protein complexes), Structural biology (cryo-electron microscopy and image analysis). The final goal is to build a mechanistic model of substrate recruitment by
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tools • Modeling of devices with the finite element method • Micro-nano fabrication in the IEMN's clean room • Physical / Electrical characterization of devices • Participation in the ANTARES project
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of these materials and structures. This approach enhances both predictive simulation and inverse design strategies, optimizing the composition and arrangement of materials in the 3D design space. Within