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on cell viability and DDR activation in established human cell models. The student will perform CRISPR screens to determine factors that affect resistance/sensitivity and follow these up with mechanistic
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chromatin profiling methods along with CRISPR/Cas9-meduated cell line engineering and various animal models. You will study the effects of the activation or depletion of chromatin-modifying enzymes using
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the mechanical performance, durability, and sustainability of both commercially available and novel cements in concrete embedded in a range of aggressive ground conditions. These are contexts in which durability
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for matching novel protein targets with their optimal expression conditions. Altogether, this project will provide new insights into the mechanisms limiting expression of challenging proteins and how