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bacteria like Streptococcus pneumoniae, they often undergo a specialized form of cell death called apoptosis, which maximizes their ability to kill the invading pathogens. We have identified that a protein
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an accumulation of abnormal, apoptosis resistant, B lymphocytes in the blood and lymphoid organs of the patients. CLL progression is highly dependent on complex interactions between tumor cells and their
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alterations off the myocardium and an important oxidative stress, leading to the loss of cardiomyocytes through apoptosis or necrosis. Currently, HF treatments are limited, and despite our increased
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microvascular dysfunction in diabetes and menopause, particularly in cell-cell communication, mitochondrial function, cell apoptosis/senescence, and calcium handling in the endoplasmic reticulum of endothelial
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and flow cytometry techniques • Viability and apoptosis assays • Protein analysis techniques using ELISA, multiplex, and western blot • RNA extraction from cells and tissues and PCR techniques
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assays (IC50), and mechanism of action tests (PCR, cell cycle analysis, apoptosis/necrosis detection, GSH levels, mitochondrial membrane potential, AP sites); • experience in analyzing results
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infections, and functional assays (e.g., proliferation, apoptosis, reporter assays). Conduct nucleic acid and protein analyses including qPCR, RT-qPCR, Western blotting, immunoprecipitation, and flow cytometry
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with 1+ year of specialized experience in adherent cells ? 3+ years of experience in mammalian cell health assays (e.g., viability, apoptosis, DNA damage) ? 3+ years of experience in mass spectrometry
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, triggering ER stress–mediated apoptosis and increasing susceptibility to proteasome inhibitors (4-8). Based on these findings, this thesis project aims to dissect how the nature, rate, and fidelity
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targets the VDAC-hexokinase complex at mitochondria to inhibit host cell apoptosis, Molecular Cell, 37: 768-783, 2010. (https://doi.org/10.1016/j.molcel.2010.02.015 5. C.T. Tan et al., MOAP-1 Mediates Fas