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PhD project aims to develop novel engineered proteins with tailored cell-recognition and activity profiles, using a combination of: Computational protein design to reprogram receptor recognition and
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of infection and relapses. We have discovered a new family of molecules, which are non-toxic to animals and active against M. abscessus. These compounds target, among many other, the protein responsible
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to animal fungal pathogens and further explore and test the above mentioned characteristics of this model. To achieve this, the PhD student will use the animal fungal pathogen Pseudogymnoascus destructans
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, with a dynamic international exposure animated by regular seminars and meetings. The Laboratoire de Biochimie Théorique (LBT) is internationally recognized for developing and applying computational
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dental polymicrobial biofilm model in collaboration with University of Oslo. These approaches will be evaluated using in vivo models through rigorous animal and/or clinical studies in a very close
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of the reorganization of visuo-cognitive functions and abilities in older adults during object and scene recognition, by taking into account, for the first time, peripheral vision–based cognitive processes and their
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. Roles of microproteins in Drosophila reproduction and fertility Our team investigates the role of microproteins in animal development and physiology. Microproteins are small proteins of fewer than 100
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. - Experience in one or more of: protein expression/purification, structural biology, cell culture, immunological assays, animal models, or transcriptomics. - Motivation to work in a highly international and
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for applying this approach at two sites, where he or she will spend three months each immersed in the daily activities of the communities (participant observation), to better understand their functioning and
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with UV and radioactive detector, dose calibrator, automatic gamma counter, digital autoradiography, animal blood cell counter, and a range of small animal imaging systems (bioluminescence/fluorescence