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chromatin profiling methods along with CRISPR/Cas9-meduated cell line engineering and various animal models. You will study the effects of the activation or depletion of chromatin-modifying enzymes using
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: Advanced molecular and protein analysis Mass spectrometry-based imaging Multi-omics technologies Preclinical cardiometabolic animal models They will also gain professional development in data stewardship
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https://pubmed.ncbi.nlm.nih.gov/22056668/ FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes. Nature. 2019 Jul;571(7765):408-412. https://pubmed.ncbi.nlm.nih.gov
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training period followed by a 3-year PhD. The training introduces students to the breadth of interdisciplinary nanoscience and supports their transition from learners to independent researchers. Teaching is
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on cell viability and DDR activation in established human cell models. The student will perform CRISPR screens to determine factors that affect resistance/sensitivity and follow these up with mechanistic
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cancer is dynamic and dependent on ASCL1. Nat Cancer. 2024 Nov;5(11):1641-1659 https://pubmed.ncbi.nlm.nih.gov/39394434/ ASCL1 activates neuronal stem cell-like lineage programming through remodeling
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if the position is filled before the advertised date. The University actively supports equality, diversity and inclusion and encourages applications from all sections of society Where to apply Website https
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development activities such as appropriate professional activities while in the role. This is an excellent opportunity for someone enthusiastic about learning new techniques, proactive in research and self
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A., Biffi G. ¬EGFR-activated myofibroblasts promote metastasis of pancreatic cancer. Cancer Cell (2024). 3) Cheng P.S.W., Zaccaria M., Biffi G. Functional heterogeneity of fibroblasts in primary
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to the role within your statement of interest. Deadline: The closing date is 31st October 2025 with interviews held in November. The University actively supports equality, diversity and inclusion and encourages