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implant failure and limb amputation. Current antimicrobial coatings often rely on antibiotics or metallic agents, which may contribute to antimicrobial resistance (AMR) or cytotoxicity. This project aims
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on recent advances in recombinant RNAP production, cryo-EM structural elucidation, and fragment-based screening, the project will integrate fluorine-based NMR spectroscopy with active learning algorithms and
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. This project aims to develop novel polymer-based nanoparticles for the non-viral delivery of mRNA vaccines directly to mucosal tissues, such as the respiratory tract. By leveraging high-throughput automated
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). Design and fabricate patterned surfaces optimised for enzyme immobilisation. Assess synergistic antibiofilm efficacy under static and dynamic (flow-based) biofilm models. Apply advanced microscopy, protein
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together I) microfluidic/flow-based nanoparticle synthesis, which underpins modern nanoparticle drug delivery systems including the Pfizer–BioNTech COVID-19 vaccine, together with II) high-throughput
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-scale metagenomic assembly and genome recovery • Comparative genomics and molecular evolution • Machine-learning-based protein prediction • Data integration, bioinformatics and phylogenetics • Scientific
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challenging. This project aims to develop an ultrasound-assisted nanoparticle-based drug delivery system for targeted, controlled release of antimicrobials within these hard-to-reach oral microenvironments. By
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. Approach and Methods: Apply deep learning-based modelling and clustering to analyse a curated dataset of hundreds of thousands of UL-CDR sequences Characterise sequence–structure relationships and structural
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tracking. • Quantitative image analysis to assess spatial dynamics of gene transfer. Impact and Outlook This project will: Establish proof of concept for surface-based AMR control. • Inform the design of
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healthcare. Research Environment: The project is based in UCL’s Department of Biochemical Engineering, a collaborative and interdisciplinary research environment. The student will be co-supervised by experts