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processes associated with CIN [1], leveraging single-cell DNA sequencing understand CIN heterogeneity [2], and development and implementation of machine learning and AI models to imaging data [3]. The student
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mouse models and immunology expertise (CRUK-CI), access to relevant patient material (matched fresh-frozen PDAC and serum samples). We will utilize AstraZeneca expertise in spatial and circulatory
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computational modelling to be used to design and re-engineer flower architecture. The RA's main focus will be on computational modelling of gene regulatory networks for predicting the mechanisms leading
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on cell viability and DDR activation in established human cell models. The student will perform CRISPR screens to determine factors that affect resistance/sensitivity and follow these up with mechanistic
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adoption in practice. The project aims to generate a robust scientific evidence base to inform updates to design and specification guidance, with a particular focus on re-evaluating the cement contents
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of the genome. This position will be primarily based in the Balasubramanian Lab in the CRUK Cambridge Institute (CRUK CI), and will involve collaborative interactions with the group's sister lab in the Yusuf
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: The PhD studentship will be based at the University of Cambridge in the Department of Materials Science and Metallurgy as part of the Structural Materials Group. The Structural Materials Group is a diverse
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to elucidate their role, their interactions with proteins and explore small molecule-based intervention strategies for cancer [e.g. see Genome Biology, 2025, 25, 155; Nature Chemistry, 2025, 17, 875; PNAS, 2024
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Funder: Astra Zeneca Duration: 4 years from October 1st 2026 Supervisors: Prof Paul Midgley (University of Cambridge) and Dr Okky Putra (Astra Zeneca) Location: The studentship will be based in
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comprehensive model of what tranquillity is, the factors that influence it and how to design for it. Attention to design contexts and design processes will be key to ensuring that useful measurements, methods and