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patterns and immunological outcomes. However, current interactome analyses have so far been limited to inferred interactions based on cellular receptor-ligand expression patterns. New technological advances
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-cell RNAseq datasets and analysis tools, large high-dimensional flow cytometry phenotyping panels and a collection of transgenic mouse models specifically engineered for the reporting, lineage tracing
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as well as in aging mouse models. Identification of these interactions could provide new approaches to counteract or delay age associated exhaustion of HSC. PhD Project: Contribution of cellular
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aging in Cockayne syndrome (CS) patients. Chromatin serves as a platform for DNA repair and undergoes dynamic changes during the DNA damage response (DDR) through the Access-Repair-Restore model. Histones
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model systems zebrafish and fruit fly, and structural biology (including AlphaFold predictions and cryo-EM), we will dissect the roles of these novel mRNA export regulators and define how they interface
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structurally resolved modes of binding to train the next generation of artificial intelligence (AI)-based structure prediction tools. PhD Project: AI-assisted protein-protein interaction interface clustering and
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associated with cancer and neurodegenerative diseases. We have developed an unbiased mass spectrometry-based proteomics approach to identify proteins that regulate R-loops in human cells and discovered a role