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intervention trials (e.g., diet, FMT), and ex vivo gut models enabling advanced multi-omics analyses of these samples. In addition the lab also maintains a large culture collection, partially linked to genomic
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are seeking a motivated and enthusiastic colleague with strong computational skills in the analyses of complex data sets to join our teams. About the project We have generated advanced brain on chip models
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critical roles of ion channels—particularly the TRP superfamily—in physiological and pathological processes. Our interdisciplinary approach spans from foundational electrophysiology to translational models
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training data. You will unravel the cis-regulatory code controlling context-dependent gene expression and use this information to design synthetic promoters. You will train and evaluate predictive models in
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temperature signalling in plants, such as the model plant Arabidopsis thaliana and the crop plants wheat and soybean. To unravel this, we focus on dynamic changes in protein phosphorylation status, since
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-scale screens to study fundamental principles in molecular and complex trait genetics using microbes as model systems. Our core technology MAGESTIC (https://doi.org/10.1038/nbt.4137 ), a CRISPR/Cas9-based
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the fundamental aspects of transcriptional control, this project also opens new avenues for the design of climate-resilient crops. Supported by single-cell profiling and predictive artificial intelligence models
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project that combines cutting-edge approaches including state-of-the-art imaging techniques, pluripotent stem cell models, in vivo mouse models of neurological disorders, drug (brain) delivery and nanobody
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this specificity and test how these regulate structure and function of higher-order thalamocortical inputs in cortical circuits. The applicant will use various technologies, including super-resolution imaging
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question: « what makes our brain human ? » (Vanderhaeghen and Polleux, Nat. Rev. Neurosci. 2023). We combine cutting-edge approaches such as pluripotent stem cell models of human corticogenesis, human-mouse