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Supervisor: Professor Sir Shankar Balasubramanian Course start date: 1st October 2026 Overview Professor Sir Shankar Balasubramanian is seeking a student to work on the structure and function
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dynamics of chromatin modifications required for transposon silencing. Project details This project aims to advance our understanding of small RNA-mediated chromatin silencing using advanced genomics and
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: Advanced molecular and protein analysis Mass spectrometry-based imaging Multi-omics technologies Preclinical cardiometabolic animal models They will also gain professional development in data stewardship
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from which a continuous emulsion flow and recycled gas flow is taken. The work will include the design and scaleup and perhaps the construction of a large-scale system which can be tested at ground
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the design of the nozzle. The work will include the design of a scale- up dispersion system and perhaps the construction of a large-scale dispersion system which can be tested at ground level. There is no
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comprehensive model of what tranquillity is, the factors that influence it and how to design for it. Attention to design contexts and design processes will be key to ensuring that useful measurements, methods and
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processes associated with CIN [1], leveraging single-cell DNA sequencing understand CIN heterogeneity [2], and development and implementation of machine learning and AI models to imaging data [3]. The student
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dynamics and tissue morphogenesis during embryo development using cellular, molecular and mechanical approaches. Cell movements underlie tissue patterns and shapes. Using chick embryos as the model system
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tumours and metastases with the goal to design combinatorial therapeutic approaches. The project will involve the use of genetically complex organoid-derived transplantation mouse models of pancreatic
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mouse models and immunology expertise (CRUK-CI), access to relevant patient material (matched fresh-frozen PDAC and serum samples). We will utilize AstraZeneca expertise in spatial and circulatory