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. Approach and Methods: Apply deep learning-based modelling and clustering to analyse a curated dataset of hundreds of thousands of UL-CDR sequences Characterise sequence–structure relationships and structural
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. These mobile genetic elements autonomously transfer between bacteria, disseminating resistance genes across microbial populations. Recent advances have demonstrated the potential of “counter-plasmids” that can
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-penetrating capabilities Evaluate delivery efficiency in cell-based models mimicking lung and immune tissues Identify structure–function relationships to inform rational design of future mucosal delivery
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on recent advances in recombinant RNAP production, cryo-EM structural elucidation, and fragment-based screening, the project will integrate fluorine-based NMR spectroscopy with active learning algorithms and
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treatment outcomes in vulnerable populations. Training and Student Development: The student will receive interdisciplinary training in: Peptide synthesis and structural analysis Advanced mass spectrometry
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(SONATA, EP/V028626/1) and brings together expertise in microfluidics, fluid dynamics, nanoparticle engineering, and dental microbiology. Approach and Methods: Engineer in vitro models of bacterial biofilm
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will focus on the atomistic simulation of mineral oxide/liquid water interfaces that are of relevance to solar fuel production, decontamination of soil and geochemical transformations. The simulations
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). Design and fabricate patterned surfaces optimised for enzyme immobilisation. Assess synergistic antibiofilm efficacy under static and dynamic (flow-based) biofilm models. Apply advanced microscopy, protein
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-pharmacological antifungal therapies. Approach and Methods: Develop and optimise laboratory models of fungal growth and resistance. Investigate how environmental stress factors (e.g. osmotic and nutrient stress
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chemistry and nanoscale structure, these coatings will offer long-term, biocompatible protection against infection. The project will involve materials design, fabrication, characterisation, and biological