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of mammalian brains using mice as an animal model. Three main lines of research include 1) the brain-wide mapping of brain cell types including GABAergic neurons, glia, and cerebrovascular network, 2) anatomical
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at The Pennsylvania State University. The Du lab is interested in understanding how transcription machineries and regulatory DNA elements organize in 3D in the nucleus to regulate gene expression. We leverage single
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molecular biology techniques, 2D and 3D cell culture models (hydrogels), imaging techniques (TEM, SEM, confocal), protein analysis (immunohistochemistry/immunofluorescence), and handling of rodents. Specific
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approaches for important questions in neuroscience. We have multiple current and incoming NIH projects to establish cellular cell type architecture maps of mammalian brains using mice as an animal model. Three
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focuses are: 1) Investigating the underlying molecular mechanisms by which 3D genome topology controls the hematopoietic transcription program and lineage differentiation in normal and malignant