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niches that promote tumor progression using single cell and spatial approaches. These projects, and my laboratory, lie at the intersection of cancer genetics and tumor immunology, and at the interface
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for the computer simulation of electronically excited processes in molecules and materials. In the age of net-zero it is more important than ever to obtain a deep, molecular-level understanding of the working
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that fundamentally transforms our knowledge about how cells function by peering into their molecular components in time and space, from single molecules to native tissue environments. About the Project – DDLS Data
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fundamental plant biology with relevance for future crop innovation. Plants have the fascinating ability to regenerate from a single cell or a damaged tissue. This ability requires extensive changes in, amongst
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host chromatin pathways (DFG Research Unit DEEP-DV, FOR5200). The group uses experimental infection systems, an array of high-throughput sequencing methods, and single-molecule live-cell imaging
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Max Planck Institute for Multidisciplinary Sciences | Gottingen, Niedersachsen | Germany | 6 days ago
, Dreier JE, Meisl G, Guido R, Knowles TPJ, Galvagnion C, Buell AK, Vendruscolo M, Michaels TCT. Global kinetic model of lipid-induced α-synuclein aggregation and its inhibition by small molecules. Proc Natl
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Max Planck Institute for Multidisciplinary Sciences | Gottingen, Niedersachsen | Germany | 6 days ago
, 28943-54 (2025) DOI : 10.1021/jacs.5c06971 The small molecule inhibitor anle145c thermodynamically traps human islet amyloid peptide in the form of non-cytotoxic oligomers, S. Manikam, S. Ryazanov, A
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PhD Student (f/m/d) | NMR structure of AP-L complex of hIAPP and its effect on fibrils and membranes
Max Planck Institute for Multidisciplinary Sciences, Göttingen | Gottingen, Niedersachsen | Germany | 3 days ago, V. Singh Mithu, K. Giller, E. Nimerovsky, K. Overkamp, L.B. Andreas, S. Becker, C. GriesingerJACS 147, 28943-54 (2025) DOI : 10.1021/jacs.5c06971 The small molecule inhibitor anle145c
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the knowledge of molecular and cell biology, physiology, reproductive immunology, histology and functional morphology (in the context of evolution and ontogeny) into a single entity, the link between which is the
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these, Nucleotide-binding, Leucine-rich-Repeat proteins (NLRs) constitute a large family of intracellular receptors of pathogen-associated molecules, termed effectors. To restrict infection, NLRs trigger a response