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limited understanding of sperm molecular biology. In this PhD project, you will investigate how molecular assemblies in human sperm are organized in situ and how this architecture relates to fertility and
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the development of genetic autoinflammatory diseases. Using techniques in cell biology, molecular biology and biophysics you will investigate how loss of function of the RNA editing enzyme ADAR1 causes the human
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context of the affected human tissue, and the power of our experimental models, this work will deliver urgently needed insights into the pathogenesis of YARS1-CMT. The project may also reveal shared
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