PhD student M/F

Organisation/Company

CNRS

Department

Institut Cochin

Research Field

Chemistry
Physics » Biophysics
Biological sciences » Biological engineering

Researcher Profile

First Stage Researcher (R1)

Application Deadline

24 Apr 2026 - 23:59 (UTC)

Country

France

Type of Contract

Temporary

Job Status

Full-time

Hours Per Week

35

Offer Starting Date

1 Oct 2026

Is the job funded through the EU Research Framework Programme?

Not funded by a EU programme

Is the Job related to staff position within a Research Infrastructure?

No

The project is supported by the 80 I PRIME (Projet de recherche inter-instituts multi-équipes) interdisciplinary CNRS programme (http://www.cnrs.fr/mi ).
The PhD candidate will be co-supervised by Florence Niedergang (Team « Biology of Phagocytes, Infection and Immunity» at Institut Cochin, www.institutcochin.fr ) and Jacques Fattaccioli (Institut Pierre Gilles de Gennes, CNRS, ENS Chemistry Department, Sorbonne Université), in close collaboration with Jean-Maurice MALLET and Blaise DUMAT (CNRS, ENS, Sorbonne Université).

The principal working place will be Institut Cochin, which is one of the biggest biomedical French Research Center located in the center of Paris. The other laboratories are located in Institut Pierre-Gilles de Gennes, a leading institute dedicated to microfluidics and its applications, and the Chemistry department of ENS/PSL, a top tier French university and research center.
The 3 laboratories are located in the Latin Quarter in Paris, within 15 min walking distance.

Mammalian cells must recycle membranes and nutrients after degradation in lysosomes to maintain homeostasis and conserve resources. This recycling activity is particularly crucial in phagocytic cells, where engulfed material is degraded and reused rather than expelled. Phagocytosis, a receptor-mediated internalization and digestion of objects larger than 0.5 microns, leads to the formation of a phagosome that matures through a series of fusion and fission with the endosomal compartments to generate a phagolysosome. This implies important remodeling of the phagolysosome, with fragmentation and fission steps, and the resulting vesicles then replenish the pool of lysosomes, in a step called phagosome resolution. How phagolysosomes resolve however still lacks detailed characterization. While the fate of phagosomes and their internalized cargo depends on the surface receptors initially engaged, the mechanisms by which phagocytic receptors modulate phagosome terminal resolution remain poorly understood.
We will investigate these critical steps of phagosomal resolution using micron-sized lipid particles functionalized with phagocytic ligands and decorated with fluorescent tracers for pH and proteolytic activity. This design will enable innovative real-time analysis of biochemical and mechanical processes underlying phagosome maturation and resolution in living cells.

Website

https://emploi.cnrs.fr/Offres/Doctorant/UMR8104-FLONIE-006/Default.aspx

Research Field

Chemistry

Education Level

Master Degree or equivalent

Research Field

Physics

Education Level

Master Degree or equivalent

Research Field

Biological sciences

Education Level

Master Degree or equivalent

Languages

FRENCH

Level

Basic

Research Field

Chemistry

Years of Research Experience

None

Research Field

Physics » Biophysics

Years of Research Experience

None

Research Field

Biological sciences » Biological engineering

Years of Research Experience

None

Website for additional job details

https://emploi.cnrs.fr/Offres/Doctorant/UMR8104-FLONIE-006/Default.aspx

Number of offers available

1

Company/Institute

Institut Cochin

Country

France

City

PARIS 14

Geofield

City

PARIS 14

Website

http://www.institutcochin.fr

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