PhD project: Design and synthesis of modified XNA as potential therapeutics

Updated: 2 months ago
Job Type: FullTime
Deadline: 03 Mar 2026

14 Feb 2026
Job Information
Organisation/Company

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences
Research Field

Chemistry » Inorganic chemistry
Researcher Profile

First Stage Researcher (R1)
Application Deadline

3 Mar 2026 - 22:50 (UTC)
Country

Czech Republic
Type of Contract

Temporary
Job Status

Full-time
Offer Starting Date

1 Oct 2026
Is the job funded through the EU Research Framework Programme?

Not funded by a EU programme
Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

The topic of the dissertation will be the design and enzymatic synthesis of hypermodified xeno-nucleic acids with a combination of modifications at the base, sugar moiety and phosphate linkages. After optimization of the methodology, hypermodified XNA oligonucleotides will be prepared and tested as potential therapeutics.

University: Faculty of Chemical Technology, UCT Prague; Faculty of Science, Charles University

Group: Michal Hocek Group / Bioorganic and Medicinal Chemistry of Nucleic Acids

Tutor: Prof. Ing. Michal Hocek, Ph.D. DSc.

Field of study: Organic chemistry

Apply: https://www.uochb.cz/en/call-for-phd-applications


Where to apply
Website
https://www.uochb.cz/en/call-for-phd-applications

Requirements
Languages
ENGLISH
Level
Good

Additional Information
Work Location(s)
Number of offers available
1
Company/Institute
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences
Country
Czech Republic
City
Praha 6
Postal Code
160 00
Street
Flemingovo náměstí 542/2

STATUS: EXPIRED

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