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Chekouo and his collaborators within and outside the University of Minnesota. The research will focus on the development of Bayesian statistical/machine learning methods for the data integration analysis
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constitutive androstane receptor (CAR) as models. PXR and CAR transcriptionally regulate cytochrome P450 3A4 (CYP3A4) and CYP3A5-drug-metabolizing enzymes that metabolize more than 50% of clinical drugs
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approach to develop chemical probes, investigate biological mechanisms, and evaluate in vivo efficacy. In particular we use the promiscuous pregnane X receptor (PXR) and constitutive androstane receptor (CAR
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