Postdoctoral Researcher in Neuroinflammation and Nigrostriatal Assembloids

University of Luxembourg, Luxembourg

Updated: 29 days ago
Deadline: ;

We are seeking a highly motivated Postdoctoral Researcher to carry out the experimental implementation of a research project aimed at characterizing patient-derived microglia-integrated nigrostriatal assembloids to investigate neuroinflammation in the pathogenesis of Multiple System Atrophy (MSA) and to evaluate therapeutic modulation of neuroinflammatory pathways.

This position centers on establishing and systematically characterizing microglia-containing nigrostriatal assembloids to dissect the interplay between neuroinflammation, neurodegeneration and α-synuclein pathology. The research combines advanced 3D stem cell modeling, neuroimmune interaction studies, high-content imaging, molecular and biochemical analyses and the evaluation of immunomodulatory therapeutic strategies in MSA.

Key responsibilities:

  • Generation, maintenance and differentiation of human iPSCs into midbrain and striatum organoids, nigrostriatal assembloids and microglia
  • Integration of microglia into assembloid systems and optimization of co-culture conditions
  • Phenotypic characterization of disease-relevant features, including neuronal loss, microglial activation and astroglial responses, α-synuclein pathology
  • Immunofluorescence and confocal microscopy, high-content imaging, quantitative image analysis, SDS-PAGE and Western blot
  • Testing of candidate compounds
  • Contribution to single-nucleus RNA sequencing and transmission electron microscopy workflows and data interpretation in collaboration with partners
  • Data analysis, figure preparation, manuscript and report drafting and presentation of results at international conferences
  • Participation in regular project meetings and interaction with consortium partners

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