27 Mar 2026
Job Information
- Organisation/Company
Institut Curie - Research Center- Department
Administration- Research Field
Medical sciences » Cancer research- Researcher Profile
First Stage Researcher (R1)- Positions
Postdoc Positions- Application Deadline
27 May 2026 - 00:00 (Europe/Paris)- Country
France- Type of Contract
Temporary- Job Status
Full-time- Offer Starting Date
27 Mar 2026- Is the job funded through the EU Research Framework Programme?
Horizon 2020- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
The hosting structure
The Curie Institute Research Center
The Institut Curie is a major player in the research and fight against cancer. It consists of a hospital and a Research Center of more than 1000 employees with a strong international representativeness.
The objective of the Curie Institute Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient
Context
Laboratory
The Cavalli Lab is part of the "Computational Oncology" Unit (U1331 INSERM, Mines ParisTech, Institut Curie) at Institut Curie, which consists of ~90 researchers and students. It is a very active and growing interdisciplinary team of bioinformaticians, biologists, physicians, mathematicians, statisticians, physicists, and computer scientists (U1331 Unit page ).
The Cavalli Lab (located at Institut Curie St-Cloud, west of Paris), investigates tumor heterogeneity, targeting clinically relevant questions. The goal of our genomic approaches is to explore clinically relevant aspects of brain tumor biology. We pursue this goal using patient samples profiling, investigating temporal and intra-tumoral/spatial heterogeneity as well as tumor/tumor microenvironment interactions in gliomas and pediatric embryonal brain tumors. Projects in the Cavalli lab are developed within a dynamic and collaborative environment with other researchers and clinicians at Institut Curie and national/international wet lab collaborators.
The project
We seek a talented individual to tackle the complexity of tumor biology and intra-tumoral heterogeneity performing computational analysis of cutting-edge sequencing datasets. S/he will be in charge of the analysis of single-nucleus RNA/ATAC-seq and spatial transcriptomics data from brain tumor patient samples or models in close collaboration with experimentalists.
This project focuses on deciphering tumor cell plasticity, including method evaluation/development and biological interpretation of the results. In addition, s/he will drive a cross species pediatric tumor model comparison deciphering tumor cell programs. Finally, s/he will investigate the metabolome of IDH-mutant glioma tumors and perform data integration with omics layers to further decipher treatment resistance mechanisms.
Responsibilities
- Drive and develop scientific projects focused on tumor heterogeneity
- Perform end-to-end data analysis (QC, processing, visualization, interpretation…)
- Analyze single-cell and spatial transcriptomics datasets
- Decipher metabolomic patterns
- Perform high dimensional data analysis and integrative ‘omic’ data analysis
Candidate Profile
Training and Skills required
- (Recent) PhD in bioinformatics, statistics, or computer science with knowledge and interest in biology
- Track record of creativity in developing analytic strategies
- Strong foundation of knowledge in one or more of the following: genomics, cancer biology, statistics
- Experience working in a Unix environment and statistical analysis using R
- Excellent computational biology skills
- Experience with single-cell RNA-seq analysis
- Experience with machine learning based methods
- Have evidence of scientific accomplishment via peer-reviewed publications
- Understanding of cancer cell biology is an asset as well as experience of collaboration with biologists for solving concrete biological problems
Abilities
- Must be self-motivated, capable to work in autonomy
- Excellent written and verbal communication skills in English
- Capacity to communicate with oncologists and biologists
- Critical thinking
- Team spirit is essential
All our opportunities are open to people with disabilities
Contract information
Type of contract: Fixed-term contract.
Starting date: As soon as possible
Duration: 24 months
Working time: full time
Remuneration: according to the current grids
Benefits: Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance
Location of the position: Saint-Cloud
Contact
Please send your CV, letter of motivation and contact information of three referees :
Publication date: 27/03/2026
Deadline for application: until filled
Institut Curie is an inclusive, equal opportunity employer
and is dedicated to the highest standards of research integrity.
https://euraxess.ec.europa.eu/sites/default/files/brochures/eur_21620_en-fr.pdf
Where to apply
job-ref-kekwuvyjm6@emploi.beetween.com
Requirements
- Research Field
- Medical sciences » Cancer research
- Education Level
- PhD or equivalent
- Languages
- FRENCH
- Languages
- ENGLISH
- Level
- Excellent
- Research Field
- Medical sciences » Cancer research
Additional Information
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Institut Curie - Centre de recherche
- Country
- France
- City
- Saint Cloud
- Geofield
Contact
- State/Province
160013- City
Paris- Website
http://curie.fr/?prehome=0- Street
26 rue d'Ulm- Postal Code
75005
job-ref-kekwuvyjm6@emploi.beetween.com- Phone
0156246527
STATUS: EXPIRED
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