Doctorant (M/F) in physical chemistry of polymers

CNRS, France

Updated: 22 days ago
Location: Strasbourg, ALSACE
Job Type: FullTime
Deadline: 17 Apr 2026

28 Mar 2026
Job Information
Organisation/Company

CNRS
Department

Institut Charles Sadron
Research Field

Chemistry
Physics » Chemical physics
Physics » Biophysics
Researcher Profile

First Stage Researcher (R1)
Application Deadline

17 Apr 2026 - 23:59 (UTC)
Country

France
Type of Contract

Temporary
Job Status

Full-time
Hours Per Week

35
Offer Starting Date

1 Oct 2026
Is the job funded through the EU Research Framework Programme?

Not funded by a EU programme
Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

The Institut Charles Sadron (ICS, UPR22) is a CNRS unit affiliated with the University of Strasbourg. This multidisciplinary institute, dedicated to the science of polymers and self-assembled systems, comprises 49 researchers, 34 research support staff, and 100 non-permanent staff (doctoral students, postdocs, and interns). The ICS has characterization platforms (UV-Vis and IR spectroscopy, size exclusion chromatography, light scattering, etc.) and microscopy platforms (electron and atomic force microscopy). Supervised by Fouzia Boulmedais (senior CNRS researcher) and Delphine Chan-Seng (associate CNRS researcher), the doctoral student will work in the Sustainable (Bio)materials: Self-Assembly of Peptides and Polymers (IRIS) team at the ICS. He/she will be depending from the ED222 doctoral school. For more information, please visit the website: https://www.ics-cnrs.unistra.fr/
The institute is easily accessible by public transportation and the doctoral student will have access to the campus dining.

mRNA-based therapies have emerged as an effective approach for treating diseases with known genetic targets, such as cancers, immune and infectious diseases, and neurological disorders. The success of mRNA therapy depends on the development of safe and effective delivery systems. One possible strategy is to use a polycation as a vector by complexing it with the mRNA. A key challenge is identifying a polymer capable of sufficiently complexing mRNA to protect it from enzymatic degradation, yet not so tightly that it prevents the release of the mRNA once it reaches its target, thereby ensuring therapeutic action. The project aims to use a comb-shaped polyarginine developed by our team that exhibits thermoresponsive behavior to release the mRNA in a spatiotemporally controlled manner. The objective of the doctoral project will be to prepare monodisperse coacervates with a diameter of less than 200 nm. A study of the internal structure of these coacervates will be conducted to gain a better understanding of this system. As the project is a collaboration with Matthew Tirrell's group, the doctoral student will be required to conduct experiments at the University of Chicago (USA).


Where to apply
Website
https://emploi.cnrs.fr/Offres/Doctorant/UPR22-DELCHA-009/Default.aspx

Requirements
Research Field
Chemistry
Education Level
PhD or equivalent

Research Field
Physics
Education Level
PhD or equivalent

Research Field
Physics
Education Level
PhD or equivalent

Languages
FRENCH
Level
Basic

Research Field
Chemistry
Years of Research Experience
None

Research Field
Physics » Chemical physics
Years of Research Experience
None

Research Field
Physics » Biophysics
Years of Research Experience
None

Additional Information
Website for additional job details

https://emploi.cnrs.fr/Offres/Doctorant/UPR22-DELCHA-009/Default.aspx

Work Location(s)
Number of offers available
1
Company/Institute
Institut Charles Sadron
Country
France
City
STRASBOURG
Geofield


Contact
City

STRASBOURG
Website

http://www.ics-cnrs.unistra.fr

STATUS: EXPIRED

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